Download or read book An Overview of Biosurgical Hemostats in Burn Surgery written by John Sojka and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Management of coagulopathy is a crucial aspect of care for hospitalized burn patients, especially intraoperatively during burn surgery. It is estimated that approximately one-third of blood products utilized during an average burn injury hospitalization are administered intraoperatively during excision of the primary wound and donor sites. Moreover, transfusion of blood products alone during burn surgery does not constitute an adequate method to achieve hemostasis. Biosurgical hemostats should be utilized as adjunctive therapeutic agents to minimize blood loss. Potential options include topical or tumescent epinephrine, fibrin sealants, calcium alginate, platelet rich plasma, topical or intravenous tranexamic acid, NuStat®, recombinant tissue factor, hydrogen peroxide, and oxidized regenerated cellulose. The most abundant clinical evidence is available for the use of topical and tumescent epinephrine and fibrin sealants to achieve hemostasis during burn surgery. The epinephrine technique has been shown to be generally safe, without clinically significant cardiovascular effects from systemic absorption. For fibrin sealants (FS), it is important that surgeons recognize that not all FS are the same, and that different formulations or products may behave in a slightly different fashion. For the other available hemostatic available hemostatic options, further research is needed to fully elucidate their potential roles and utility in minimizing blood loss during burn surgery.