Download or read book EFICACY AND SAFETY OF RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR R (TPA) IN ACUTE ISCHEMIC STROKE DUE TO SMALL VESSEL VERSUS LARGE VESSEL DISEASES written by Asmaa SABBAH and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Acute ischaemic stroke accounts for approximately 80% of all strokes and intravenous alteplase is the only Food and Drug Administration approved thrombolytic agent for the treatment of acute ischemic stroke despite the risk of post thrombolysis bleeding .Aim of the Work: to evaluate the efficacy and safety of thrombolysis with intravenous recombinant human tissue plasminogen activator (r TPA) for ischemic stroke in small and large vessel diseases.Patients: and Methods: This study is a cross section observational study of total of 50 patients whose having either small or large vessel diseases and received IV r(TPA). Patients were recruited from stroke unite over 1 year at Al Ain hospital, United Arab Emirates Results :Our results show that Small vessel disease was associated with a better outcome than large vessel disease with no mortality recorded among them and 3 patients died among large vessel diseases group , there was positive correlation between post TPA bleeding and NIHSS at onset , and NIHSS after 24 hours after treatment in large vessel group as p value was 0.05 and 0.000 respectively . In large vessel group there was statistical significance between NIHSS at onset and favorable outcome . There was strong positive correlation between the occurrence of post r TPA bleed and mRS at 3month as r value is 0.578 and (p value =0.000).Conclusions . Small vessel disease after IV thrombolysis have more often a good outcome, do not have higher risk of post rTPA bleeding and have low mortality than large vessel diseases.