Principles of Characterizing and Applying Human Exposure Models

Principles of Characterizing and Applying Human Exposure Models
Author :
Publisher : World Health Organization
Total Pages : 77
Release :
ISBN-10 : 9789241563116
ISBN-13 : 9241563117
Rating : 4/5 (117 Downloads)

Book Synopsis Principles of Characterizing and Applying Human Exposure Models by : International Program on Chemical Safety

Download or read book Principles of Characterizing and Applying Human Exposure Models written by International Program on Chemical Safety and published by World Health Organization. This book was released on 2005 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this manual is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose and concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix, and a glossary of terms is also provided.--Publisher's description.


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