Download or read book A Role for the NF-kb/Rel Transcription Factors in Human Breast Cancer written by and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human breast cancer is characterized by the inappropriate expression of growth factors, kinases and possibly certain transcription factors. Our project focuses on the potential role of a family of transcription factors known as NF-kB/Rel in human breast cancer. Additionally, the project will analyze a role for VNTR elements in the hereditary susceptibility of women to breast cancer and on a role for estrogen in modulating cell growth of human breast cancers. It has been reported previously that certain genes known to be regulated by NF-kB/Rel proteins are inappropriately activated in human breast cancer. We have explored mechanisms that may be involved in the activation of NF-kB/Rel proteins in human breast cancer. Our data ruled out the general mechanism of induced nuclear translocation, but new data indicates that NF-kB can be activated through a novel mechanism involving targeting of the transcriptional activation function of the NF-kB p65 subunit. We are presently exploring the role and requirement of NF-kB in human breast cancer and whether this transcription factor is involved in responses to oncogenes, to estrogen and whether it controls gene expression induced by VNTR elements.