Download or read book Rapid Throughput Solubility Screening Assay Development and Its Applications in Preformulation written by Jeremy Guo and published by . This book was released on 2007 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method was then used to evaluate the solubilities of Biopharmaceutic Classification Scheme (BCS) class II drugs in animal and simulated human GI fluids. The goal was to establish correlates between in vitro and in vivo drug solubility in the GI tract. Four BCS class II drugs with solubilities ranging from a few mug/mL to over 100 mug/mL were evaluated in simulated GI fluid in both fasted and fed conditions. Method reproducibility was within 15% relative standard deviation. Solubility values from the screening method correlated well with literature values.