Download or read book Synthesis and Reactivity of a New Sterically-demanding Bis(thione) Ligand written by Neha Ahuja and published by . This book was released on 2010 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The coordination chemistry of the bis(mercaptoimidazolyl)xylenes (BmxR), a family of neutral bis(thione) ligands, has been extended. A novel, sterically-demanding ligand, ortho-bis(2-mercapto-l-tert-butylimidazolyl)xylene (o-BrnxtBu), has been successfully synthesized and characterized. The presence of a rigid xylylene backbone and a bulkier substituent lends an extended directionality and a pronounced steric effect to the ligand system. The coordination chemistry of the ligand system was explored with both transition (Re, Co, Cu, Ag, Au) and main group metals (Cd, Hg, In, Pb, Bi) to assess the mode of binding, reactivity, solubility patterns and the steric effects exerted by the bulky tert-butyl substituent. Xenobiotic heavy metals like Cd(II), Hg(II) and Pb(II) have a high affinity for sulfur rich active sites. They bind strongly with the cysteine and methionine residues found in proteins, thereby disrupting the normal body functions. Coordination chemistry of o-BmxtBu with these heavy metal centers was carried out to understand and assess the exact mechanism of binding of these metals within the body. The data and the structures obtained with o-BrnxtBu will be compared and contrasted, whenever possible, with the bis(mercaptoimidazolyl)methanes BmmR (R = Me, But) and the o-BmxMe ligand.