Download or read book The Role of Drosophila Inhibitor of Apoptosis (DIAP1) in Fat Body Remodeling written by Anne Sarie Y.. Cossogue and published by . This book was released on 2012 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: I hypothesized that diap1 is expressed in the larval fat body throughout metamorphosis and that this helps to inhibit PCD in this organ. To test this hypothesis, I examined diap1 transcript levels in wild type Drosophila using qPCR. In addition, I determined the expression of diap1 in larval fat body of flies with a diap1 RNAi construct. My results demonstrate that diap1 is expressed in the larval fat body during prepupal and early pupal development. Preliminary findings showed that Drosophila expressing the diap1 RNAi construct failed to undergo normal fat body remodeling. This finding suggests that diap1 is necessary for the normal timing of fat body remodeling and the successful development of Drosophila.